The liquefied material exerts equal pressure on the walls of the cyst from within. Who defined it as a cystic lesion in which the epithelial lining shows a welldefined basal layer of columnar cells, an overlying layer that is often many cells thick and that may resemble. The calcifying odontogenic cyst designated by gorlin et al. The classification and behavior of epithelial odontogenic tumors and cysts in human beings, dogs, and cats are discussed. Gorlin and coworkers 1962 lesion unusual some features of a cyst and also of a solid neoplasm. Calcifying cystic odontogenic tumor in a 5yearold boy. In most instances, the calcifying odontogenic cyst is composed of a fibrous capsule that is lined with a proliferation of odontogenic epithelial cells fig. Calcifying epithelial odontogenic cyst associated with complex.
Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by. Histologically, ccot is usually composed of a cystic cavity with fibrotic capsule lined by an odontogenic epithelium. In fact, a cystic wall covered with an epithelium with ameloblastic differentiation and ghost cells, some of which were calcified. Calcifying epithelial odontogenic tumor an overview. The calcifying epithelial odontogenic cyst is an uncommon benign lesion. It appears as a cyst lined by an ameloblastic epithelium, containing variable amounts of ghost cells and calcifications. Ameloblastoma, calcifying epithelial odontogenic tumor. The calcifying cystic odontogenic tumor ccot, formerly known as calcifying odontogenic cyst, is a rare developmental neoplasmcyst of odontogenic epithelial origin with considerable histopathologic diversity and variable clinical behaviour. A calcifying epithelial odontogenic tumor ceot is a locally invasive epithelial neoplasm characterized by the development of intraepithelial structures, probably of an amyloidlike nature, which may become calcified and liberated as the cells break down. Malignancy arising from the epithelial lining of an odontogenic cyst.
The lesion mostly effects patients under the age of 40. Odontogenic neoplasms have some morphologic overlap with salivary gland neoplasms, many of which show myoepithelial differentiation. Recently, neoplastic potential of this lesion has been pointed out by several investigators and this lesion has been considered to be a borderline lesion between cyst and tumor. The 1992 world health organization who classification of odontogenic cysts is widely recognized and categorizes them as developmental or inflammatory in nature. In the 1980s, an ultrastructural study identified a population of myoepithelial. Abstract the calcifying epithelial odontogenic cyst ceoc was first delineated in 1962. The cyst may sometimes be associated with benign odontogenic tumors.
It is an unusual and unique lesion, which may show characteristics of both a solid neoplasm and a cyst. Since the original description of the calcifying odontogenic cyst by gorlin et al. The calcifying odontogenic cyst coc, described separately by gorlin et al in 1962 and by gold2 in 1963, is derived from odontogenic epithelial remnants within the mandible or maxilla, or from the gingiva. The danish oral and maxillofacial pathologist jean j. The calcifying cystic odontogenic tumor normally presents as a. It is more common in the posteriorpart of the mandible,typically in the fourth to fifth decades. Here is reported the case of a 21yearold female patient with a ceot in the left mandibular posterior region. Calcifying ghost cell odontogenic cyst cgcoc is a heterogeneous group of lesion existing either as cystic or solid variant. Pdf the calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin.
It is a cystic lesion which histologically shows an ameloblastomatous lining along. J oral maxillofac surg calcifying odon togenic cyst. Calcifying epithelial odontogenic tumor, also known as pindborg tumor, is a rare, benign, locally aggressive tumor that occurs in the same age range and in the same jaw sites as ameloblastoma. A cyst is an epitheliumlined sac containing fluid or semisolid material. It normally affects patients between 30 and 50 years old, and it is typically located in the posterior region of the mandible. Calcifying epithelial odontogenic tumor ceot, also known as a pindborg tumor, previously has been called adenoid adamintoblastoma, unusual ameloblastoma and cystic odontoma is typically located in the premolar and molar region of the mandible, although up to a third are found in the maxilla. Calcifying epithelial odontogenic cyst a case report with. Depending on the clinical and radiographic features, provisional diagnosis of benign odontogenic tumor such as calcifying epithelial odontogenic tumor was given and in diff erential diagnosis, calcifying odontogenic cyst, cementoossifying fibroma, ameloblastic fibroodontome and adenom atoid odontogenic tumor were given. It was previously described as an adenoid adamantoblastoma, unusual ameloblastoma and a cystic odontoma. Although there are numerous reports on the variants of ceot, occurrence of clear cells with complete absence of calcification has been a rarity. The calcifying epithelial odontogenic tumor ceot is a rare and benign odontogenic epithelial neoplasm. The calcifying cystic odontogenic tumor can occur in any location of the oral cavity and approximately 6567. Calcifying odontogenic cyst gorlin cyst classified as a tumor by the who.
There is some disagreement on the terminology and classification of this lesion. Even the cystic lesion has apparent neoplastic potential but most. Learn vocabulary, terms, and more with flashcards, games, and other study tools. We herein report a rare case of extraosseous calcifying epithelial odontogenic tumor with local aggressive behavior. The peripheral coc is a rare lesion and few reports have been published considering its clinical and histopatholo. The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin. It is an unusual and unique lesion, which may show. This tumor accounts for less than 1% of all odontogenic tumors. The term calcifying odontogenic cyst was first introduced by gorlin in 1962 eshghyar et al. Different manifestations of calcifying cystic odontogenic. A survey of epithelial odontogenic tumors and cysts in. The center of the ball of cells then has a higher protein.
Pdf calcifying epithelial odontogenic cyst a case report. Cysts grow by expansion and thus displace the adjacent teeth by pressure. Calcifying epithelial odontogenic cyst features of ceoc, with the presence of a cystic epithelial lining associated with complex odontome of maxilla. Gold 1963 chose a similar, but not identical term for the lesion, namely keratinizing and calcifying odontogenic cyst. Calcifying epithelial odontogenic tumor ceot is a rare, benign, locally aggressive odontogenic epithelial tumor that affects the jaws. Calcifying epithelial odontogenic cyst associated with. The calcifying cystic odontogenic tumor ccot is a new designation of calcifying odontogenic cyst coc recommended by the 2005 classification of the world health organization who. Recurrent calcifying odontogenic cyst 145 have been reported in the literature, one by gorlin et al. Calcifying odontogenic cyst the journal of contemporary dental. The first description of calcifying epithelial odontogenic tu mours ceot in the english language was published in 1946 by the swiss doctor kurt h.
Abstract the calcifying odontogenic cyst coc accounts for. Calcifying epithelial odontogenic cysts are thought to be a unicystic process, which develop from the reduced enamel epithelium or remnants of odontogenic epithelium in the follicle, gingival tissue or bone. The calcifying odontogenic cyst coc is a simple cyst lined by ameloblastomalike epithelium with ghost cells. Calcifying epithelial odontogenic cyst of the mandible figueiredo. The calcifying odontogenic cyst is not a common lesion. Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression.
Clear cell variant of calcifying epithelial odontogenic. It is a developmental odontogenic cyst, and its occurrence constitutes about 0. Calcifying odontogenic cyst coc was first described by gorlin in 1962. An odontogenic cyst is a pathological, epitheliallined cavity containing fluid or semifluid which arises from the epithelial remnants of tooth formation.
We briefly discuss the radiologic features of calcifying epithelial odontogenic tumor and the relevant literature. Calcifying epithelial odontogenic tumor of the maxilla. Calcifying epithelial odontogenic tumor ceot is a rare benign odontogenic neoplasm, locally aggressive, cha. Pdf calcifying epithelial odontogenic cyst of the mandible. Recurrent calcifying odontogenic cyst universiteit utrecht. Expression of ck14 and vimentin in adenomatoid odontogenic.
Calcifying odontogenic cyst coc is a form of odontogenic cyst. Calcifying odontogenic cyst coc, first described as a separate entity by gorlin et al. Calcifying odontogenic cyst an uncommon benign odontogenic lesion was first categorized as a distinct entity by gorlin et al. This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3.
The calcifying cystic odontogenic tumor ccot is a new designation of calcifying odontogenic cyst coc recommended by the 2005 classification of. Calcifying odontogenic cyst radiology reference article. The calcifying epithelial odontogenic tumor ceot is a rare benign epithelial odontogenic neoplasm of slow growth that is locally aggressive and tends to invade bone and adjacent soft tissue. On radiographs, the calcifying odontogenic cyst appears as a unilocular radiolucency dark area. Calcifying epithelial odontogenic cyst ceoc, is a rarebenign odontogenic cyst of locally aggressive behavior. Calcifying epithelial odontogenic cyst of the mandible. Pdf ameloblastoma, calcifying epithelial odontogenic. Calcifying epithelial odontogenic tumor of the posterior. J maxillofac oral surg with ameloblastlike cells, ghost cells, dystrophic calciication and 20. Ccot may clinically be diagnosed as ameloblastoma, calcifying epithelial odontogenic tumor, adenomatoid odontogenic tumor, ameloblastic fibroodontoma, complex or compound odontoma and dentigerous cyst or as other types of odontogenic cysts.
Calcifying epithelial odontogenic tumor ceot is a rare odontogenic neoplasm comprising pdf. The calcifying odontogenic cyst coc 1 is a cystic lesion lined by an ameloblastomalike epithelium containing ghost cells and calcifications. Although named and defined as a cyst, there is no agreement in the literature regarding its classification as a cyst or a neoplasm, as some examples of coc shows areas suggestive of. Calcifying cystic odontogenic tumor a case report and. Calcifying ghost cell odontogenic cyst is comparatively rare in occurrence, constituting about 0. The calcifying ghost cell odontogenic cyst cgcoc was first described by gorlin et al. Three important things associated with this diagnosis. It was thoroughly described by gorlin and coworkers in 19621 and. Calcifying odontogenic cyst was first described by gorlin et al. Histochemical analysis of tumor cells revealed glycogen granules with pas staining, with absence of cd 1a staining. Calcifying epithelial odontogenic tumors may be locally invasive. A propensity for the mandibular molar region versus the premolar maxilla has been reported. Extension of calcifying epithelial odontogenic tumor to.
The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by gorlin in 1962. Although the condition is often described as being cystic 85% of the cases, a significant percentage of calcifying odontogenic cysts grow as more solid, seemingly neoplastic proliferations, and the term dentinogenic ghost cell tumor has been used to describe these lesions. The occurrence of ccot in the first decade of life is very uncommon. Calcifying odotogenic cyst is a benign odontogenic tumor of cystic type most likely to affect the anterior areas of the jaws. Expression of ck14 and vimentin in adenomatoid odontogenic tumor and dentigerous cyst. It is most common in people in their second to third decades but can be seen at almost any age. Pdf calcifying odontogenic cyst or gorlin cyst, was first described by gorlin. Adenomatoid odontogenic tumor mimicking a periapical radicular cyst. Calcifying odontogenic cyst gorlins cyst report of. The world health organization classification of head and neck tumors classifies the lesion as an odontogenic tumor and names it calcifying cystic odontogenic tumor. These cells are loosely arranged and show a peripheral basal cell layer that has a cuboidal or columnar appearance, microscopic features similar to. Ct and mr imaging showed the distinctive appearances of this histologic entity. In onethird of cases, an impacted tooth is involved. The calcifying epithelial odontogenic cyst ceoc is a developmental odontogenic cyst, which was first categorized as a distinct entity by.
However, in the majority of cases it occurs in the second decade of life12. Different manifestations of calcifying cystic 367 einstein. Like other odontogenic neoplasms, it is thought to arise from the epithelial element of the enamel origin. Because of its behavior, many oral pathologists now consider the okc an odontogenic tumor that has a cystic form 2005 classi.
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